The Use of Psychotropic Medication in Pediatric Oncology for Acute Psychological and Psychiatric Problems: Balancing Risks and Benefits

Severe acute behavioral and emotional problems represent one of the most serious treatment-related adverse effects for children and adolescents who have cancer. The critical and severe nature of these symptoms often makes necessary the use of psychotropic drugs. A working group composed of experts in multiple disciplines had the task of creating an agreement regarding a management plan for severe acute behavioral and emotional problems (SABEPs) in children and adolescents treated for cancer. To obtain global information on the use of psychotropic drugs in pediatric oncology, the working group first developed and mailed a 15-item questionnaire to many Italian pediatric oncology centers. Overall, an evident lack of knowledge and education regarding the use of psychotropic medications for the treatment of SABEPs was found. Thus, by referring to an adapted version of the Delphi method of consensus and standard methods for the elaboration of clinical questions (PICOs), the working group elaborated evidence-based recommendations for psychotropic drugs in the pediatric oncology setting. Furthermore, based on a thorough multivariate analysis of needs and difficulties, a comprehensive management flow was developed to optimize therapeutic interventions, which allows more accurate and efficient matching of the acute needs of patients while guiding treatment options

DIG-MAN: Integration of digital tools into product development and manufacturing education

General objectives of PRODEM education. Teaching of product development requires various digital tools. Nowadays, the digital tools usually use computers, which have become a standard element of manufacturing and teaching environments. In this context, an integration of computer-based technologies in manufacturing environments plays the crucial and main role, allowing to enrich, accelerate and integrate different production phases such as product development, design, manufacturing and inspection. Moreover, the digital tools play important role in management of production. According to Wdowik and Ratnayake (2019 paper: Open Access Digital Tool’s Application Potential in Technological Process Planning: SMMEs Perspective, https://doi.org/10.1007/978-3-030-29996-5_36), the digital tools can be divided into several main groups such as: machine tools and technological equipment (MTE), devices (D), internet(intranet)-based tools (I), software (S). The groups are presented in Fig. 1.1. Machine tools and technological equipment group contains all existing machines and devices which are commonly used in manufacturing and inspection phase. The group is used in physical shaping of manufactured products, measurement tasks regarding tools and products, etc. The next group of devices (D) is proposed to separate the newest trends of using mobile and computer-based technologies such as smartphones or tablets and indicate the necessity of increased mobility within production sites. The similar need of separation is in the case of internet(intranet)-based tools which indicate the growing interest in network-based solutions. Hence, D and I groups are proposed in order to underline the significance of mobility and networking. These two groups of the digital tools should also be supported in the nearest future by the use of 5G networks. The last group of software (S) concerns computer software produced for the aims of manufacturing environments. There is also a possibility to assign the defined solutions (e.g. computer programs) to more than one group (e.g. program can be assigned to software and internet-based tools). The main role of tools allocated inside separate groups is to support employees, managers and customers of manufacturing firms focused on abovementioned production phases. The digital tools are being developed in order to increase efficiency of production, quality of manufactured products and accelerate innovation process as well as comfort of work. Nowadays, digital also means mobile. Universities (especially technical), which are focused on higher education and research, have been continuously developing their teaching programmes since the beginning of industry 3.0 era. They need to prepare their alumni for changing environments of manufacturing enterprises and new challenges such as Industry 4.0 era, digitalization, networking, remote work, etc. Most of the teaching environments nowadays, especially those in manufacturing engineering area, are equipped with many digital tools and meet various challenges regarding an adaptation, a maintenance and a final usage of the digital tools. The application of these tools in teaching needs a space, staff and supporting infrastructures. Universities adapt their equipment and infrastructures to local or national needs of enterprises and the teaching content is usually focused on currently used technologies. Furthermore, research activities support teaching process by newly developed innovations. Figure 1.2 presents how different digital tools are used in teaching environments. Teaching environments are divided into four groups: lecture rooms, computer laboratories, manufacturing laboratories and industrial environments. The three groups are characteristic in the case of universities’ infrastructure whilst the fourth one is used for the aims of internships of students or researchers. Nowadays lecture rooms are mainly used for lectures and presentations which require the direct communication and interaction between teachers and students. However, such teaching method could also be replaced by the use of remote teaching (e.g. by the use of e-learning platforms or internet communicators). Unfortunately, remote teaching leads to limited interaction between people. Nonverbal communication is hence limited. Computer laboratories (CLs) usually gather students who solve different problems by the use of software. Most of the CLs enable teachers to display instructions by using projectors. Physical gathering in one room enables verbal and nonverbal communication between teachers and students. Manufacturing laboratories are usually used as the demonstrators of real industrial environments. They are also perfect places for performing of experiments and building the proficiency in using of infrastructure. The role of manufacturing labs can be divided as: • places which demonstrate the real industrial environments, • research sites where new ideas can be developed, improved and tested. Industrial environment has a crucial role in teaching. It enables an enriched student experience by providing real industrial challenges and problems

COVID-19 in patients with thoracic malignancies (TERAVOLT): first results of an international, registry-based, cohort study

Background: Early reports on patients with cancer and COVID-19 have suggested a high mortality rate compared with the general population. Patients with thoracic malignancies are thought to be particularly susceptible to COVID-19 given their older age, smoking habits, and pre-existing cardiopulmonary comorbidities, in addition to cancer treatments. We aimed to study the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on patients with thoracic malignancies. Methods: The Thoracic Cancers International COVID-19 Collaboration (TERAVOLT) registry is a multicentre observational study composed of a cross-sectional component and a longitudinal cohort component. Eligibility criteria were the presence of any thoracic cancer (non-small-cell lung cancer [NSCLC], small-cell lung cancer, mesothelioma, thymic epithelial tumours, and other pulmonary neuroendocrine neoplasms) and a COVID-19 diagnosis, either laboratory confirmed with RT-PCR, suspected with symptoms and contacts, or radiologically suspected cases with lung imaging features consistent with COVID-19 pneumonia and symptoms. Patients of any age, sex, histology, or stage were considered eligible, including those in active treatment and clinical follow-up. Clinical data were extracted from medical records of consecutive patients from Jan 1, 2020, and will be collected until the end of pandemic declared by WHO. Data on demographics, oncological history and comorbidities, COVID-19 diagnosis, and course of illness and clinical outcomes were collected. Associations between demographic or clinical characteristics and outcomes were measured with odds ratios (ORs) with 95% CIs using univariable and multivariable logistic regression, with sex, age, smoking status, hypertension, and chronic obstructive pulmonary disease included in multivariable analysis. This is a preliminary analysis of the first 200 patients. The registry continues to accept new sites and patient data. Findings: Between March 26 and April 12, 2020, 200 patients with COVID-19 and thoracic cancers from eight countries were identified and included in the TERAVOLT registry; median age was 68·0 years (61·8-75·0) and the majority had an Eastern Cooperative Oncology Group performance status of 0-1 (142 [72%] of 196 patients), were current or former smokers (159 [81%] of 196), had non-small-cell lung cancer (151 [76%] of 200), and were on therapy at the time of COVID-19 diagnosis (147 [74%] of 199), with 112 (57%) of 197 on first-line treatment. 152 (76%) patients were hospitalised and 66 (33%) died. 13 (10%) of 134 patients who met criteria for ICU admission were admitted to ICU; the remaining 121 were hospitalised, but were not admitted to ICU. Univariable analyses revealed that being older than 65 years (OR 1·88, 95% 1·00-3·62), being a current or former smoker (4·24, 1·70-12·95), receiving treatment with chemotherapy alone (2·54, 1·09-6·11), and the presence of any comorbidities (2·65, 1·09-7·46) were associated with increased risk of death. However, in multivariable analysis, only smoking history (OR 3·18, 95% CI 1·11-9·06) was associated with increased risk of death. Interpretation: With an ongoing global pandemic of COVID-19, our data suggest high mortality and low admission to intensive care in patients with thoracic cancer. Whether mortality could be reduced with treatment in intensive care remains to be determined. With improved cancer therapeutic options, access to intensive care should be discussed in a multidisciplinary setting based on cancer specific mortality and patients' preference

Characterization of <i>Neochloris oleoabundans</i> under Different Cultivation Modes and First Results on Bioactivity of Its Extracts against HCoV-229E Virus

Microalgae are proposed in several biotechnological fields because of their ability to produce biomass enriched in high-value compounds according to cultivation conditions. Regarding the health sector, an emerging area focuses on natural products exploitable against viruses. This work deals with the characterization of the green microalga Neochloris oleoabundans cultivated under autotrophic and mixotrophic conditions as a source of whole aqueous extracts, tested as antivirals against HCoV-229E (Coronaviridae family). Glucose was employed for mixotrophic cultures. Growth and maximum quantum yield of photosystem II were monitored for both cultivations. Algae extracts for antiviral tests were prepared using cultures harvested at the early stationary phase of growth. Biochemical and morphological analyses of algae indicated a different content of the most important classes of bioactive compounds with antiviral properties (lipids, exo-polysaccharides, and total phenolics, proteins and pigments). To clarify which phase of HCoV-229E infection on MRC-5 fibroblast cells was affected by N. oleoabundans extracts, four conditions were tested. Extracts gave excellent results, mainly against the first steps of virus infection. Notwithstanding the biochemical profile of algae/extracts deserves further investigation, the antiviral effect may have been mainly promoted by the combination of proteins/pigments/phenolics for the extract derived from autotrophic cultures and of proteins/acidic exo-polysaccharides/lipids in the case of mixotrophic ones

Endothelial function evaluation in idiopathic vs. ischemic dilated cardiomyopathy

In the latest years an emerging interest has risen towards the role of endothelial dysfunction (ED) in the pathogenesis of heart failure (HF) since the very first steps of the disease. Since the prevalent etiology of HF is ischemic cardiomyopathy (ICM), it is still not clear whether the connection with ED is linked to HF itself or to atherosclerosis. The aim is to determine the presence of ED in subjects with idiopathic dilated cardiomyopathy (IDCM) compared to ICM

Mostra "Piante officinali spontanee del Delta del Po"

E' presentata un'ottantina di schede illustrate di piante che vivono nell’affascinante ambiente naturale del Delta, fornito di una elevata diversità. Le piante, utilizzate a scopo medicinale a livello scientifico o anche solo popolare sono state suddivise in base alle loro principali proprietà ed usi a seconda dei sistemi del corpo su cui agiscono